Dr Raphael MechaulamEntourage Effect
In 1999 Mechoulam co-authored a paper with Shimon Ben-Shabat suggesting that cannabinoids made in the body work by means of an “entourage effect.” They had found that the endocannabinoid 2-AG (2-arachidonoylglycerol), when administered with two related compounds, would bind more readily at the cannabinoid receptors and exert more pronounced behavioral effect on mice.
orchestra
[ awr-kuh-struh ]
noun
a group of performers on various musical instruments for playing music, as symphonies, operas, popular music, or other compositions.
UNDERSTANDINGTerpenes and Terpenoids
Terpenes/terpenoids have a wide range of biological and pharmacological activities, for instance, antifungal, antiviral, anticancer, anti-inflammatory, antihyperglycemic, antiparasitic, antioxidant, and antimicrobial. It is not possible to describe all pharmacological effects of terpenes/terpenoids in this paper, but we shall give just some examples for imagination of how important these compounds are in this plant
Essential oils have been used in multiple ways, i.e., inhaling, topically applying on the skin, and drinking. Thus, there are three major routes of intake or application involved: the olfactory system, the skin, and the gastro-intestinal system.
A violin solo sounds beautiful, but the entire ensemble is a symphony of sound.
A Concerto is a musical composition for a solo instrument or instruments accompanied by an orchestra, especially one conceived on a relatively large scale.
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ETHAN RUSSO
“Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti inflammatory activity.”
RAPHAEL MECHAULAM
Very seldom is the biological activity of the active constituent assayed together with inactive ‘entourage’ compounds.
